The electrolyte and renal status of each patient should be ascertained prior to initiating treatment and periodically thereafter
905: DIGOXIN DOSING IN PATIENTS UNDERGOING CONTINUOUS RENAL REPLACEMENT THERAPY: A BRIEF REPORT
Digoxin is a cardiac glycoside which is readily available and has proven effective; however, its narrow therapeutic window, and its predominant excretion through
1 To avoid toxicity, digoxin should be
Major exclusion criteria were the loss of serum digoxin concentrations and elderly patients with an acute kidney injury (AKI) or who received continuous renal
Additionally, digoxin is not readily removed by dialysis
This renal dysfunction can notably complicate heart failure (HF) therapy, especially when treatment involves digoxin, a drug primarily eliminated by the
The global Continuous renal replacement therapy market size is projected to reach USD 2
The continuous nature of the fluid and solute removal has less impact on
NICE has also produced a
Digoxin works by inhibiting an enzyme (called Na-K ATPase) responsible for the exchange of sodium for other electrolytes in cells
Digoxin can be used to treat heart failure when symptoms remain despite the use of other drugs
Acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT) is a common complication in critical illness and has a significant impact on pharmacokinetic factors determining drug exposure, including absorption, distribution, transport, metabolism, and clearance
Background: Sustained low-efficiency daily dialysis (SLEDD) is an increasingly popular renal replacement therapy for intensive care unit (ICU) patients
In many ICUs, especially in Australia and in Europe, CRRT
Hypokalaemia, hypomagnesaemia, hypercalcaemia, and hypoxia (risk of digitalis toxicity)
125 mg/d in patients with chronic kidney disease (CKD) (Table S1)
To be given over at least 2 hours
Continuous kidney replacement therapy (CKRT) is an alternative to an intermittent therapy such as standard hemodialysis
Renal replacement therapy includes dialysis (hemodialysis or peritoneal dialysis)
In these patients, regardless of Evaluating recrudescent (breakthrough) digoxin toxicity in renal-failure patients
Dosing recommendations are provided separately in the In patients with concomitant septic shock and MALA, continuous renal replacement therapy (CRRT) has been reported to be successful due to hemodynamic instability